Human Sera
Cayman Chemical DnofloxacInmesylate 50mg
A selective PAK1 inhibitor that induces apoptosis in breast cancer cells and has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells
Cayman Chemical -TaxIfolIn 100mg
An antagonist of mGluR7 inhibiting lateral amygdala long term potentiation in brain slices from wild-type mice with an IC50 value of 88 nM demonstrates good brain penetrance producing wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral tests
Cayman Chemical namInhydrochlorIde 100mg
An inhibitor of FGFRs (IC50s 13 21 31 and 35 nM for recombinant FGFR1-4 respectively) selective for FGFRs over a panel of 456 kinases (1 M) inhibits EGFR (IC50 204 nM) inhibits growth of Ba/F3 cells dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s TEL/V564M-dependent Ba/F3 cells inhibits growth in a panel of cancer cell lines (EC50s 1 4-499 nM)
Cayman Chemical IpsapIronhydrochlorIde 50mg
A natural pentacyclic triterpenoid that inhibits collagen-induced platelet aggregation (IC50 10 5 UM) inhibits acetylcholinesterase (IC50 165 UM) and has antifungal and hepatoprotective effects
Cayman Chemical MyrIstelaIdIc AcId 100mg
A mixture that contains ( )14(15)-DiHET (Item No 51651) ( )11(12)-DiHET (Item No 51511) ( )8(9)-DiHET (Item No 51351) ( )5(6)-DiHET (Item No 51211) 19(R)-HETE (Item No 10007767) 20-HETE (Item No 90030) ( )14(15)-EET (Item No 50651) ( )11(12)-EET (Item No 50511) and ( )8(9)-EET (Item No 50351)
Cayman Chemical 1R 9SHydrastIn 50mg
A fluorogenic dye used to label F-actin ex/em spectra of 650/665 nm respectively can be used to label formaldehyde-fixed tissue cells and cell-free preparations for single- and multi-labeling purposes
Cayman Chemical AlosetronhydrochlorIde 100mg
A histamine H1 receptor antagonist (Ki 6 06 nM) also inhibits the reuptake of serotonin and norepinephrine
Cayman Chemical Suplatstosylate 100mg
An intermediate in the synthesis of diclofenac acyl-b-D-glucuronide
Cayman Chemical DIhydroRgocrIstInmSylate 100mg
An HDAC6 inhibitor (IC50 12 nM) selective for HDAC6 over HDAC1 -4 -5 -7 -8 -9 and -11 (IC50s 1 39 19 5 6 91 8 34 1 23 38 2 and 5 12 UM respectively) inhibits HDAC6 in but does not induce cell death of human PC3 prostate 5637 and T24 bladder and murine SM1 melanoma cells in vitro from 0 1-25 UM decreases PD-L1 protein levels in SM1 cells at 5 UM reduces tumor growth and increases the number of intratumoral CD8 CD4 and NK T cells in an SM1 murine melanoma model
Cayman Chemical DImaprIthydrochlorIde 100mg
A triacylglycerol has been found in a variety of plant oils including poppy seed hazelnut maize olive yellow melon and date seed oils
Cayman Chemical AzatdInmaleate 100mg
An activator of K2P2 1/TREK1 and K2P10 1/TREK2 (EC50s 14 3 and 5 2 UM respectively in Xenopus oocytes)
Cayman Chemical BacItracIn Complex 100mg
A ceramide analog and inhibitor of CERT inhibits binding of a ceramide probe to the isolated START domain of CERT (EC50 4 M in a TR-FRET assay) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells at 2 5 M inhibits sphingomyelin synthesis in wild-type but not ATP-dependent ceramide transport-deficient CHO cells at 1 M
Cayman Chemical 5 N NhexamethylenAmIlorI 50mg
A mitochondria-targeted fluorescent probe AIE active abs/em 485/705 nm respectively can be used in live cells and in vivo
Cayman Chemical Apararenon 50mg
A fluorogenic substrate forBhexosaminidases is cleaved byBhexosaminidases to release the fluorescent moiety 4-U ex 320 and 360 nm at low (1 97-6 72) and high pH (7 12-10 3) respectively em 445 to 455 nm increasing as pH decreases has been used to quantifyBhexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease